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Understand bone marrow pathophysiology induced by drugs, radiation, or genetic mutations.
The Bone Marrow-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support for building a Bone Marrow-Chip using the Human Emulation System.
Understand bone marrow pathophysiology induced by drugs, radiation, or genetic mutations.
The Bone Marrow-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support for building a Bone Marrow-Chip using the Human Emulation System.
Vascularization and media flow in Organ-Chips support the differentiation and maturation of multiple blood cell lineages over four weeks while improving CD34+ cell maintenance for more accurate recapitulation of bone marrow injury.
A four-week culture period supports erythroid differentiation as well as myeloid development and mobilization
The Bone Marrow-Chip recapitulates the toxic responses of human bone marrow to clinically relevant concentrations of known toxic agents
The Bone Marrow-Chip has been shown to appropriately model radiation-induced decreases in all cell types
Researchers have demonstrated the ability to captured key hematological abnormalities associated with Shwachman-Diamond Syndrome
The Bone Marrow-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support for building a Bone Marrow-Chip using the Human Emulation System.
Bone Marrow-Chip diagram showing differentiation following 2-4 weeks of culture. The hematopoietic compartment contains stem and progenitor patient-derived CD34+ cells and bone marrow-derived stromal cells embedded within a fibrin gel. The vascular compartment improves bone marrow function by producing angiocrine factors, supplying nutrients, and removing waste. (Source: Nature Biomedical Engineering)
The total number of hematopoietic cells within the Bone Marrow-Chip increased approximately 300-fold over 28 days of culture. (Source: Nature Biomedical Engineering)
Bone Marrow-Chips infused with 5-FU through the vascular channel for two days displayed the predicted hematotoxicity at clinically relevant low micromolar concentrations, whereas analogously treated suspension and static gel co-cultures did not. (Source: Nature Biomedical Engineering)
Bone Marrow-Chips exposed to gamma radiation showed moderately decreased cell numbers at 1 Gy and severe toxicity at 4 Gy, closely matching human radiation sensitivities. (Source: Nature Biomedical Engineering)
The Bone Marrow-Chip recapitulates hematopoietic abnormalities observed in patients with SDS, as shown by a decrease in both lineage cell numbers and impaired neutrophil maturation. (Source: Nature Biomedical Engineering)
