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Recapitulate human vaccine and adjuvant responses
The Lymphoid Organ-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Lymphoid Organ-Chip using the Human Emulation System.
Recapitulate human vaccine and adjuvant responses
The Lymphoid Organ-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Lymphoid Organ-Chip using the Human Emulation System.
The Lymphoid Organ-Chip model supports the formation of lymphoid follicles with functional germinal centers similar to those found in secondary and tertiary lymphoid organs in vivo, enabling researchers to recapitulate human vaccine and adjuvant responses.
Dynamic flow on-chip stimulates the assembly of large 3D multicellular aggregates.
Lymphoid Organ-Chips demonstrate significant anti-HA antibody generation following treatment with inactivated H5N1 virus.
The Lymphoid Organ-Chip displays clinically relevant levels of cytokines that are important for T cell expansion, survival, and helper functions.
Eight different human donors all produced anti-HA antibodies at detectable levels, with subsets of high and low responders identified.
Myeloid cells capture and express mRNA vectored by lipid nanoparticles, enabling assessment of mRNA vaccines.
Neutralizing antibody production against the SARS-CoV-2 spike protein has shown to be achieved after a culture duration of just six days.
The Lymphoid Organ-Chip design consists of a high-density 3D human PBMC culture within an ECM gel in the lower channel, while media and antigens are flowed in the upper channel of the chip.
The Lymphoid Organ-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Lymphoid Organ-Chip using the Human Emulation System.
Read this publication to learn how researchers at the Wyss Institute developed a human model of ectopic lymphoid follicle formation, offering a new tool for studying lymphoid follicle development and a promising alternative to non-human primates for preclinical vaccine evaluation. Learn More
In this publication, researchers from the Institut Pasteur demonstrate how the Lymphoid Organ-Chip model can be used for the preclinical evaluation of vaccine-boosting strategies. Learn More
Media flow induces follicle formation in the Lymphoid Organ-Chip (Source: Advanced Science)
Vaccine and adjuvant-induced antibody production and follicle formation in the Lymphoid Organ-Chip. (Source: Advanced Science)
