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Study host-microbiome interactions and test new therapies in human vaginal mucosa
The Vagina-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Vagina-Chip using the Human Emulation System.
Study host-microbiome interactions and test new therapies in human vaginal mucosa
The Vagina-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Vagina-Chip using the Human Emulation System.
The Vagina-Chip faithfully reproduces the vaginal microenvironment to enable preclinical validation of potential therapeutics or evaluation of vaginal epithelium-microbiome interactions.
The co-culture of human vaginal epithelial cells with fibroblasts results in a strong epithelial barrier that was maintained for up to 15 days.
The vaginal epithelium maintains the physiological acidic pH for optimal cell viability.
The Vagina-Chip recapitulates in vivo human vaginal epithelium responsiveness to variations in sex hormone levels, enabling researchers to mimic hormonal fluctuations during the menstrual cycle.
Organ-Chips enable stable co-culture of epithelial cells and bacteria without leading to bacterial overgrowth, enabling researchers to assess optimal and non-optimal microbiomes.
The Vagina-Chip design consists of primary human vaginal epithelial cells in the upper channel, while primary human uterine fibroblasts form the stromal layer in the lower channel of the chip. The porous membrane allows cellular cross-talk between the two compartments.
The Vagina-Chip is a Guided Model that Emulate has firsthand experience developing and supporting. It can be created using a Basic Research Kit and a user’s own cell sources. For Guided Models, Emulate offers guidelines and field scientist support to build a Vagina-Chip using the Human Emulation System.
Read this publication to learn how researchers at the Wyss Institute developed a human model of the vaginal epithelium to better understand interactions between the vaginal microbiome and host tissues as well as to evaluate the safety and efficacy of live biotherapeutics products. Learn More
The Vagina-Chip exhibits a well-differentiated epithelium with tissue-specific basal, suprabasal, and superficial markers. (Source: Microbiome)
